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KMID : 1149220220300040225
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Korean Journal of Oriental Medical Prescription
2022 Volume.30 No. 4 p.225 ~ p.231
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Eriobotrya japonica inhibits the transactivation of nuclear orphan receptor : the possibility to treat the chronic diseases
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Kim Min-Jin
Kim Young-Woo
Park Sun-Dong
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Abstract
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Objectives : Oxidative damage has a variety of mechanism in the human organs including brain and liver. The purpose of this study is to examine the prevention against cellular damage, and the inhibitory effect on lipogenesis of the water extract of Eriobotrya japonica (EJE).
Methods : The effect of EJE on cell viability was assessed using the MTT assay. To investigate the mechanism of EJE’s inhibition of lipogenesis, we analyzed the relevant proteins using immunoblot analysis.
Results : Induction of T0901317, a LXR agonist, significantly increased SREBP-1c expression, which was blocked by the pretreatment of EJE in the dose-dependent manners. This beneficial herb also regulated the genes related with SREBP-1c such as the acetyl-CoA carboxylase.
Conclusion : These results suggested that EJE might have a possibility of the treatment of chronic diseases as mediated with the inhibition of LXRα/SREBP-1c pathway.
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KEYWORD
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Eriobotrya japonica, SREBP-1c, LXRα, Chronic disease
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